K+ channel inhibition modulates the biochemical and morphological differentiation of human placental cytotrophoblast cells in vitro
نویسندگان
چکیده
منابع مشابه
K+ channel inhibition modulates the biochemical and morphological differentiation of human placental cytotrophoblast cells in vitro.
Maintaining placental syncytiotrophoblast, a specialized multinucleated transport epithelium, is essential for normal human pregnancy. Syncytiotrophoblast continuously renews through differentiation and fusion of cytotrophoblast cells, under paracrine control by syncytiotrophoblast production of human chorionic gonadotropin (hCG). We hypothesized that K(+) channels participate in trophoblast sy...
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The aim of this study was to determine whether extracellular ATP ([ATP](o)) stimulated a Ca(2+)-activated K(+) efflux in trophoblast cells that was dependent on extracellular Ca(2+) ([Ca(2+)](o)). Cytotrophoblast cells, isolated from human placenta, were examined following 18 h (relatively undifferentiated) and 66 h (multinucleate cells) of culture. Potassium efflux was measured using (86)Rb as...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2008
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00193.2008